Temporal Shifts in the Skin Microbiome

During an AD flare, S. aureus colonization increases and bacterial diversity decreases. As the flare subsides, skin microbiome composition reverts back to normal. Abundant evidence suggests that S. aureus influences disease pathogenesis and is associated with severe disease flares.¹

Addressing this dysbiosis and restoring skin microbiome health is a critical component of AD care.

Targeted Biome Bacteriolysis™: A New Antimicrobial Approach

Targeted Biome Bacteriolysis™ occurs when an endolysin peptidoglycan hydrolase effectively targets specific pathogenic bacteria while sparing unintended targets. This technology leverages the action of a bacteriophage to create an engineered endolysin.

  • Stage 1

    Copying what our body does naturally, Micreobalance® is the first engineered endolysin peptidoglycan hydrolase that can effectively target specific bacteria of the microbiome while sparing unintended targets.

  • Stage 2

    Working from the outside in, topically applied endolysins lyse the bacterial cell wall, ultimately resulting in bacterial death.

Citations

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1: Kong HH, Oh J, Deming C, Conlan S, Grice EA, Beatson MA, Nomicos E, Polley EC, Komarow HD; NISC Comparative Sequence Program; Murray PR, Turner ML, Segre JA. Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis. Genome Res. 2012 May;22(5):850-9. doi: 10.1101/gr.131029.111. Epub 2012 Feb 6. PMID: 22310478; PMCID: PMC3337431.